ZNF24

Protein-coding gene in the species Homo sapiens
ZNF24
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

1X6E, 3LHR

Identifiers
AliasesZNF24, KOX17, RSG-A, ZNF191, ZSCAN3, Zfp191, zinc finger protein 24
External IDsOMIM: 194534 MGI: 1929704 HomoloGene: 5068 GeneCards: ZNF24
Gene location (Human)
Chromosome 18 (human)
Chr.Chromosome 18 (human)[1]
Chromosome 18 (human)
Genomic location for ZNF24
Genomic location for ZNF24
Band18q12.2Start35,332,227 bp[1]
End35,345,482 bp[1]
Gene location (Mouse)
Chromosome 18 (mouse)
Chr.Chromosome 18 (mouse)[2]
Chromosome 18 (mouse)
Genomic location for ZNF24
Genomic location for ZNF24
Band18|18 A2Start24,142,759 bp[2]
End24,153,867 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • internal globus pallidus

  • corpus callosum

  • inferior ganglion of vagus nerve

  • olfactory bulb

  • pylorus

  • nipple

  • cardia

  • optic nerve

  • subthalamic nucleus

  • external globus pallidus
Top expressed in
  • medial ganglionic eminence

  • saccule

  • otic placode

  • triceps brachii muscle

  • stria vascularis

  • vastus lateralis muscle

  • pituitary gland

  • cumulus cell

  • sternocleidomastoid muscle

  • median eminence
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • zinc ion binding
  • protein binding
  • metal ion binding
  • nucleic acid binding
  • DNA-binding transcription factor activity
  • DNA-binding transcription activator activity, RNA polymerase II-specific
  • sequence-specific DNA binding
  • DNA binding
  • DNA-binding transcription factor activity, RNA polymerase II-specific
Cellular component
  • nucleus
Biological process
  • myelination
  • negative regulation of transcription, DNA-templated
  • regulation of transcription, DNA-templated
  • transcription, DNA-templated
  • transcription by RNA polymerase II
  • positive regulation of transcription by RNA polymerase II
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

7572

59057

Ensembl

ENSG00000172466

ENSMUSG00000051469

UniProt

P17028

Q91VN1

RefSeq (mRNA)

NM_001308123
NM_006965
NM_001375815

NM_021559
NM_001357447
NM_001357448

RefSeq (protein)

NP_001295052
NP_008896
NP_001362744

NP_067534
NP_001344376
NP_001344377

Location (UCSC)Chr 18: 35.33 – 35.35 MbChr 18: 24.14 – 24.15 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Zinc finger protein 24 is a protein that in humans is encoded by the ZNF24 gene.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000172466 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000051469 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: ZNF24 zinc finger protein 24".

Further reading

  • Rousseau-Merck MF, Huebner K, Berger R, Thiesen HJ (January 1991). "Chromosomal localization of two human zinc finger protein genes, ZNF24 (KOX17) and ZNF29 (KOX26), to 18q12 and 17p13-p12, respectively". Genomics. 9 (1): 154–61. doi:10.1016/0888-7543(91)90233-5. PMID 2004757.
  • Thiesen HJ (April 1990). "Multiple genes encoding zinc finger domains are expressed in human T cells". The New Biologist. 2 (4): 363–74. PMID 2288909.
  • Williams AJ, Blacklow SC, Collins T (December 1999). "The zinc finger-associated SCAN box is a conserved oligomerization domain". Molecular and Cellular Biology. 19 (12): 8526–35. doi:10.1128/mcb.19.12.8526. PMC 84969. PMID 10567577.
  • Han ZG, Zhang QH, Ye M, Kan LX, Gu BW, He KL, Shi SL, Zhou J, Fu G, Mao M, Chen SJ, Yu L, Chen Z (December 1999). "Molecular cloning of six novel Krüppel-like zinc finger genes from hematopoietic cells and identification of a novel transregulatory domain KRNB". The Journal of Biological Chemistry. 274 (50): 35741–8. doi:10.1074/jbc.274.50.35741. PMID 10585455.
  • Reuter TY, Medhurst AL, Waisfisz Q, Zhi Y, Herterich S, Hoehn H, Gross HJ, Joenje H, Hoatlin ME, Mathew CG, Huber PA (October 2003). "Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport". Experimental Cell Research. 289 (2): 211–21. doi:10.1016/S0014-4827(03)00261-1. PMID 14499622.
  • Gocke CB, Yu H, Kang J (February 2005). "Systematic identification and analysis of mammalian small ubiquitin-like modifier substrates". The Journal of Biological Chemistry. 280 (6): 5004–12. doi:10.1074/jbc.M411718200. PMID 15561718.
  • Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ (January 2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nature Biotechnology. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.
  • Zhao DX, Ding ZC, Liu YQ, Huang ZX (May 2007). "Overexpression and purification of single zinc finger peptides of human zinc finger protein ZNF191". Protein Expression and Purification. 53 (1): 232–7. doi:10.1016/j.pep.2006.12.009. PMID 17270462.

External links

  • v
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  • e
  • 1x6e: Solution structures of the C2H2 type zinc finger domain of human Zinc finger protein 24
    1x6e: Solution structures of the C2H2 type zinc finger domain of human Zinc finger protein 24
  • v
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(1) Basic domains
(1.1) Basic leucine zipper (bZIP)
(1.2) Basic helix-loop-helix (bHLH)
Group A
Group B
Group C
bHLH-PAS
Group D
Group E
Group F
bHLH-COE
(1.3) bHLH-ZIP
(1.4) NF-1
(1.5) RF-X
(1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger DNA-binding domains
(2.1) Nuclear receptor (Cys4)
subfamily 1
subfamily 2
subfamily 3
subfamily 4
subfamily 5
subfamily 6
subfamily 0
(2.2) Other Cys4
(2.3) Cys2His2
(2.4) Cys6
(2.5) Alternating composition
(2.6) WRKY
(3) Helix-turn-helix domains
(3.1) Homeodomain
Antennapedia
ANTP class
protoHOX
Hox-like
metaHOX
NK-like
other
(3.2) Paired box
(3.3) Fork head / winged helix
(3.4) Heat shock factors
(3.5) Tryptophan clusters
(3.6) TEA domain
  • transcriptional enhancer factor
(4) β-Scaffold factors with minor groove contacts
(4.1) Rel homology region
(4.2) STAT
(4.3) p53-like
(4.4) MADS box
(4.6) TATA-binding proteins
(4.7) High-mobility group
(4.9) Grainyhead
(4.10) Cold-shock domain
(4.11) Runt
(0) Other transcription factors
(0.2) HMGI(Y)
(0.3) Pocket domain
(0.5) AP-2/EREBP-related factors
(0.6) Miscellaneous
see also transcription factor/coregulator deficiencies

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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