POU3F1

Protein-coding gene in the species Homo sapiens
POU3F1
Identifiers
AliasesPOU3F1, OCT6, OTF6, SCIP, POU class 3 homeobox 1
External IDsOMIM: 602479; MGI: 101896; HomoloGene: 135923; GeneCards: POU3F1; OMA:POU3F1 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for POU3F1
Genomic location for POU3F1
Band1p34.3Start38,043,829 bp[1]
End38,046,793 bp[1]
Gene location (Mouse)
Chromosome 4 (mouse)
Chr.Chromosome 4 (mouse)[2]
Chromosome 4 (mouse)
Genomic location for POU3F1
Genomic location for POU3F1
Band4 D2.2|4 57.86 cMStart124,550,600 bp[2]
End124,554,448 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • skin of abdomen

  • tibial nerve

  • Region I of hippocampus proper

  • gums

  • caudate nucleus

  • sural nerve

  • putamen

  • nucleus accumbens

  • vulva

  • cingulate gyrus
Top expressed in
  • Region I of hippocampus proper

  • barrel cortex

  • ganglionic eminence

  • female urethra

  • medial ganglionic eminence

  • hair follicle

  • nucleus accumbens

  • hippocampus proper

  • sexually immature organism

  • skin of back
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • DNA-binding transcription factor activity
  • transcription coactivator activity
  • DNA binding
  • sequence-specific DNA binding
  • DNA-binding transcription factor activity, RNA polymerase II-specific
Cellular component
  • transcription regulator complex
  • nucleus
  • nucleoplasm
Biological process
  • axon ensheathment
  • regulation of transcription by RNA polymerase II
  • myelination
  • forebrain development
  • Schwann cell development
  • brain development
  • regulation of transcription, DNA-templated
  • transcription, DNA-templated
  • myelination in peripheral nervous system
  • keratinocyte differentiation
  • positive regulation of transcription by RNA polymerase II
  • epidermis development
  • positive regulation of transcription, DNA-templated
  • positive regulation of gene expression
  • transcription by RNA polymerase II
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

5453

18991

Ensembl

ENSG00000185668

ENSMUSG00000090125

UniProt

Q03052

P21952

RefSeq (mRNA)

NM_002699

NM_011141

RefSeq (protein)

NP_002690

NP_035271

Location (UCSC)Chr 1: 38.04 – 38.05 MbChr 4: 124.55 – 124.55 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

POU domain, class 3, transcription factor 1 (also known as Oct-6) is a protein that in humans is encoded by the POU3F1 gene.[5][6]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000185668 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000090125 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Tobler A, Schreiber E, Fontana A (Feb 1993). "The human Oct-6 POU transcription factor lacks the first 50 amino acids of its murine counterpart". Nucleic Acids Research. 21 (4): 1043. doi:10.1093/nar/21.4.1043. PMC 309249. PMID 8451175.
  6. ^ "Entrez Gene: POU3F1 POU domain, class 3, transcription factor 1".

Further reading

  • Monuki ES, Kuhn R, Weinmaster G, Trapp BD, Lemke G (Sep 1990). "Expression and activity of the POU transcription factor SCIP". Science. 249 (4974): 1300–3. Bibcode:1990Sci...249.1300M. doi:10.1126/science.1975954. PMID 1975954.
  • Suzuki N, Rohdewohld H, Neuman T, Gruss P, Schöler HR (Nov 1990). "Oct-6: a POU transcription factor expressed in embryonal stem cells and in the developing brain". The EMBO Journal. 9 (11): 3723–32. doi:10.1002/j.1460-2075.1990.tb07585.x. PMC 552128. PMID 1976514.
  • Zwilling S, König H, Wirth T (Mar 1995). "High mobility group protein 2 functionally interacts with the POU domains of octamer transcription factors". The EMBO Journal. 14 (6): 1198–208. doi:10.1002/j.1460-2075.1995.tb07103.x. PMC 398197. PMID 7720710.
  • Leger H, Sock E, Renner K, Grummt F, Wegner M (Jul 1995). "Functional interaction between the POU domain protein Tst-1/Oct-6 and the high-mobility-group protein HMG-I/Y". Molecular and Cellular Biology. 15 (7): 3738–47. doi:10.1128/mcb.15.7.3738. PMC 230612. PMID 7791781.
  • Faus I, Hsu HJ, Fuchs E (May 1994). "Oct-6: a regulator of keratinocyte gene expression in stratified squamous epithelia". Molecular and Cellular Biology. 14 (5): 3263–75. doi:10.1128/mcb.14.5.3263. PMC 358693. PMID 7909356.
  • Abdel-Rahman B, Fiddler M, Rappolee D, Pergament E (Oct 1995). "Expression of transcription regulating genes in human preimplantation embryos". Human Reproduction. 10 (10): 2787–92. doi:10.1093/oxfordjournals.humrep.a135792. PMID 8567814.
  • Jaegle M, Mandemakers W, Broos L, Zwart R, Karis A, Visser P, Grosveld F, Meijer D (Jul 1996). "The POU factor Oct-6 and Schwann cell differentiation". Science. 273 (5274): 507–10. Bibcode:1996Sci...273..507J. doi:10.1126/science.273.5274.507. PMID 8662541. S2CID 39349653.
  • Sock E, Enderich J, Rosenfeld MG, Wegner M (Jul 1996). "Identification of the nuclear localization signal of the POU domain protein Tst-1/Oct6". The Journal of Biological Chemistry. 271 (29): 17512–8. doi:10.1074/jbc.271.29.17512. PMID 8663425.
  • Malik KF, Jaffe H, Brady J, Young WS (Apr 1997). "The class III POU factor Brn-4 interacts with other class III POU factors and the heterogeneous nuclear ribonucleoprotein U". Brain Research. Molecular Brain Research. 45 (1): 99–107. doi:10.1016/S0169-328X(96)00238-0. PMID 9105675.
  • Sumiyama K, Washio-Watanabe K, Ono T, Yoshida MC, Hayakawa T, Ueda S (Feb 1998). "Human class III POU genes, POU3F1 and POU3F3, map to chromosomes 1p34.1 and 3p14.2". Mammalian Genome. 9 (2): 180–1. doi:10.1007/s003359900721. PMID 9457692. S2CID 9495282.
  • Arroyo EJ, Bermingham JR, Rosenfeld MG, Scherer SS (Oct 1998). "Promyelinating Schwann cells express Tst-1/SCIP/Oct-6". The Journal of Neuroscience. 18 (19): 7891–902. doi:10.1523/JNEUROSCI.18-19-07891.1998. PMC 6792991. PMID 9742157.
  • Kawasaki T, Oka N, Tachibana H, Akiguchi I, Shibasaki H (Mar 2003). "Oct6, a transcription factor controlling myelination, is a marker for active nerve regeneration in peripheral neuropathies". Acta Neuropathologica. 105 (3): 203–8. doi:10.1007/s00401-002-0630-9. hdl:2433/148771. PMID 12557005. S2CID 2340303.
  • Beck IM, Müller M, Mentlein R, Sadowski T, Mueller MS, Paus R, Sedlacek R (May 2007). "Matrix metalloproteinase-19 expression in keratinocytes is repressed by transcription factors Tst-1 and Skn-1a: implications for keratinocyte differentiation". The Journal of Investigative Dermatology. 127 (5): 1107–14. doi:10.1038/sj.jid.5700674. PMID 17195013.
  • Ryu EJ, Wang JY, Le N, Baloh RH, Gustin JA, Schmidt RE, Milbrandt J (Oct 2007). "Misexpression of Pou3f1 results in peripheral nerve hypomyelination and axonal loss". The Journal of Neuroscience. 27 (43): 11552–9. doi:10.1523/JNEUROSCI.5497-06.2007. PMC 6673231. PMID 17959798.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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(1) Basic domains
(1.1) Basic leucine zipper (bZIP)
(1.2) Basic helix-loop-helix (bHLH)
Group A
Group B
Group C
bHLH-PAS
Group D
Group E
Group F
bHLH-COE
(1.3) bHLH-ZIP
(1.4) NF-1
(1.5) RF-X
(1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger DNA-binding domains
(2.1) Nuclear receptor (Cys4)
subfamily 1
subfamily 2
subfamily 3
subfamily 4
subfamily 5
subfamily 6
subfamily 0
(2.2) Other Cys4
(2.3) Cys2His2
(2.4) Cys6
(2.5) Alternating composition
(2.6) WRKY
(3) Helix-turn-helix domains
(3.1) Homeodomain
Antennapedia
ANTP class
protoHOX
Hox-like
metaHOX
NK-like
other
(3.2) Paired box
(3.3) Fork head / winged helix
(3.4) Heat shock factors
(3.5) Tryptophan clusters
(3.6) TEA domain
  • transcriptional enhancer factor
(4) β-Scaffold factors with minor groove contacts
(4.1) Rel homology region
(4.2) STAT
(4.3) p53-like
(4.4) MADS box
(4.6) TATA-binding proteins
(4.7) High-mobility group
(4.9) Grainyhead
(4.10) Cold-shock domain
(4.11) Runt
(0) Other transcription factors
(0.2) HMGI(Y)
(0.3) Pocket domain
(0.5) AP-2/EREBP-related factors
(0.6) Miscellaneous
see also transcription factor/coregulator deficiencies
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