FOXH1

FOXH1
Identifiers
Aliases	FOXH1, FAST-1, FAST1, forkhead box H1
External IDs	OMIM: 603621; MGI: 1347465; HomoloGene: 2914; GeneCards: FOXH1; OMA:FOXH1 - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q24.3 Start 144,473,412 bp[1] End 144,475,849 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 D3 Start 76,552,425 bp[2] End 76,554,148 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in islet of Langerhans middle temporal gyrus rectum duodenum nucleus accumbens occipital lobe pharynx thymus mucosa of small intestine putamen Top expressed in primitive streak blastocyst spermatid spermatocyte yolk sac morula seminiferous tubule medial vestibular nucleus mammillary body allantois More reference expression data BioGPS More reference expression data
Gene ontology Molecular function co-SMAD binding transcription coregulator activity protein domain specific binding sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific androgen receptor binding DNA-binding transcription factor activity bHLH transcription factor binding DNA binding protein binding R-SMAD binding SMAD binding transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleoplasm activin responsive factor complex transcription regulator complex nucleus Biological process ventricular trabecula myocardium morphogenesis anterior/posterior pattern specification negative regulation of androgen receptor signaling pathway embryonic heart tube anterior/posterior pattern specification transcription, DNA-templated outflow tract morphogenesis nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry regulation of transcription by RNA polymerase II heart looping axial mesoderm development cardiac right ventricle morphogenesis negative regulation of transcription by RNA polymerase II determination of left/right symmetry secondary heart field specification positive regulation of transcription, DNA-templated regulation of transcription, DNA-templated aorta morphogenesis transcription by RNA polymerase II negative regulation of intracellular estrogen receptor signaling pathway transforming growth factor beta receptor signaling pathway positive regulation of transcription by RNA polymerase II cellular response to cytokine stimulus anatomical structure morphogenesis cell differentiation negative regulation of DNA-binding transcription factor activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8928 14106 Ensembl ENSG00000160973 ENSMUSG00000033837 UniProt O75593 O88621 RefSeq (mRNA) NM_003923 NM_007989 RefSeq (protein) NP_003914 NP_032015 Location (UCSC) Chr 8: 144.47 – 144.48 Mb Chr 15: 76.55 – 76.55 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Forkhead box protein H1 is a protein that in humans is encoded by the FOXH1 gene.^[5][6]

Function

FOXH1 encodes a human homolog of Xenopus forkhead activin signal transducer-1. FOXH1 protein binds SMAD2 and activates an activin response element via binding the DNA motif TGT(G/T)(T/G)ATT.^[6]

FoxH1 is a transcription factor that contains a conserved function in chordates. FoxH1, acts in combination with other transcription factors, as a critical element of node formation in early embryo development. Specifically, FoxH1 plays a role in anterior/posterior determination during gastrulation. By the third week of gestation, cells of the splanchnic mesoderm have migrated to the superior end of the embryo to form the cardiac crescent. The cardiac crescent forms two heart fields; primary heart field and the secondary heart field. At this point in development, the two heart fields fuse to form a primitive, single-chambered heart referred to as the primary myocardium. The secondary (anterior) heart field of these cardiac crescent cells will give rise to the outflow tract and the right ventricle of the mature heart. A model lacking FoxH1 will form a primary myocardium, undergo some amount of looping, but have undefined right ventricles and outflow tracts.

Interactions

FOXH1 has been shown to interact with DRAP1^[7] and Mothers against decapentaplegic homolog 2.^{[8][9][10][11][12]}

See also

• FOX proteins

References

1. ·     Slagle CE, Aoki T, Burdine RD. Nodal-dependent mesendoderm specification requires the combinatorial activities of FoxH1 and Eomesodermin. PLoS Genet. 2011;7(5):e1002072. doi:10.1371/journal.pgen.1002072
2. Hoodless PA, Pye M, Chazaud C, et al. FoxH1 (Fast) functions to specify the anterior primitive streak in the mouse. Genes Dev. 2001;15(10):1257-1271. doi:10.1101/gad.881501
3. ·     von Both I, Silvestri C, Erdemir T, et al. Foxh1 is essential for development of the anterior heart field. Dev Cell. 2004;7(3):331-345. doi:10.1016/j.devcel.2004.07.023

Further reading

External links

• FOXH1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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