DLX1

DLX1
Identifiers
Aliases	DLX1, Dlx, Dlx-1, distal-less homeobox 1
External IDs	OMIM: 600029; MGI: 94901; HomoloGene: 22558; GeneCards: DLX1; OMA:DLX1 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q31.1 Start 172,084,740 bp[1] End 172,089,677 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 C2|2 42.61 cM Start 71,358,457 bp[2] End 71,364,325 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in middle temporal gyrus endothelial cell ganglionic eminence prefrontal cortex Brodmann area 23 dorsolateral prefrontal cortex Brodmann area 9 amygdala hypothalamus putamen Top expressed in medial ganglionic eminence olfactory bulb nasolacrimal duct otic placode fossa paraventricular nucleus of hypothalamus maxillary prominence lateral hypothalamus hair follicle condyle More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding sequence-specific DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding chromatin binding protein binding DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity Cellular component nucleus Biological process negative regulation of neuron apoptotic process cerebral cortex GABAergic interneuron differentiation proximal/distal pattern formation cell differentiation regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II embryonic skeletal system development multicellular organism development odontogenesis of dentin-containing tooth cerebral cortex GABAergic interneuron fate commitment negative regulation of oligodendrocyte differentiation forebrain neuron differentiation hippocampus development subpallium development negative regulation of Notch signaling pathway positive regulation of cell differentiation negative regulation of photoreceptor cell differentiation positive regulation of amacrine cell differentiation negative regulation of transcription by RNA polymerase II negative regulation of BMP signaling pathway positive regulation of transcription by RNA polymerase II cellular response to transforming growth factor beta stimulus cellular response to BMP stimulus negative regulation of cellular response to transforming growth factor beta stimulus transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1745 13390 Ensembl ENSG00000144355 ENSMUSG00000041911 UniProt P56177 Q64317 RefSeq (mRNA) NM_001038493 NM_178120 NM_010053 RefSeq (protein) NP_001033582 NP_835221 NP_034183 Location (UCSC) Chr 2: 172.08 – 172.09 Mb Chr 2: 71.36 – 71.36 Mb PubMed search [3] [4]
Wikidata
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Homeobox protein DLX-1 is a protein that in humans is encoded by the DLX1 gene.^[5][6]

Function

This gene encodes a member of a homeobox transcription factor gene family similar to the Drosophila distal-less gene. The encoded protein is localized to the nucleus where it may function as a transcriptional regulator of signals from multiple TGF-β superfamily members. The encoded protein may play a role in the control of craniofacial patterning and the differentiation and survival of inhibitory neurons in the forebrain. This gene is located in a tail-to-tail configuration with another member of the family on the long arm of chromosome 2. Alternatively spliced transcript variants encoding different isoforms have been described.^[6]

References

Further reading

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