ZBTB17

Protein-coding gene in the species Homo sapiens
ZBTB17
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2LVR, 2LVT, 2LVU, 2M0D, 2M0E, 2M0F, 2N25, 2N26, 2Q81, 3M52, 4U2M, 4U2N, 5ION

Identifiers
AliasesZBTB17, MIZ-1, ZNF151, ZNF60, pHZ-67, zinc finger and BTB domain containing 17
External IDsOMIM: 604084; MGI: 107410; HomoloGene: 2575; GeneCards: ZBTB17; OMA:ZBTB17 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for ZBTB17
Genomic location for ZBTB17
Band1p36.13Start15,941,869 bp[1]
End15,976,132 bp[1]
Gene location (Mouse)
Chromosome 4 (mouse)
Chr.Chromosome 4 (mouse)[2]
Chromosome 4 (mouse)
Genomic location for ZBTB17
Genomic location for ZBTB17
Band4|4 D3Start141,171,965 bp[2]
End141,195,241 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • sural nerve

  • right lobe of thyroid gland

  • ganglionic eminence

  • left lobe of thyroid gland

  • upper lobe of left lung

  • spleen

  • left uterine tube

  • body of stomach

  • canal of the cervix

  • right lung
Top expressed in
  • saccule

  • otic placode

  • plantaris muscle

  • extensor digitorum longus muscle

  • interventricular septum

  • soleus muscle

  • morula

  • ganglionic eminence

  • lip

  • quadriceps femoris muscle
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • DNA-binding transcription factor activity
  • DNA binding
  • protein binding
  • metal ion binding
  • nucleic acid binding
  • RNA polymerase II cis-regulatory region sequence-specific DNA binding
  • DNA-binding transcription activator activity, RNA polymerase II-specific
  • transcription coactivator binding
  • transcription factor binding
  • DNA-binding transcription factor activity, RNA polymerase II-specific
Cellular component
  • nucleus
  • nucleoplasm
  • protein-DNA complex
  • protein-containing complex
Biological process
  • positive regulation of transcription, DNA-templated
  • multicellular organism development
  • gastrulation with mouth forming second
  • ectoderm development
  • IRE1-mediated unfolded protein response
  • negative regulation of cell cycle
  • regulation of transcription, DNA-templated
  • transcription, DNA-templated
  • transcription by RNA polymerase II
  • negative regulation of cell population proliferation
  • positive regulation of transcription by RNA polymerase II
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

7709

22642

Ensembl

ENSG00000116809

ENSMUSG00000006215

UniProt

Q13105

Q60821

RefSeq (mRNA)
NM_001242884
NM_001287603
NM_001287604
NM_003443
NM_001324137

NM_001324138

NM_009541
NM_001378826
NM_001378827
NM_001378828

RefSeq (protein)
NP_001229813
NP_001274532
NP_001274533
NP_001311066
NP_001311067

NP_003434

NP_033567
NP_001365755
NP_001365756
NP_001365757

Location (UCSC)Chr 1: 15.94 – 15.98 MbChr 4: 141.17 – 141.2 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Zinc finger and BTB domain-containing protein 17 is a protein that in humans is encoded by the ZBTB17 gene.[5]

Interactions

ZBTB17 has been shown to interact with TOPBP1,[6] Host cell factor C1[7] and Myc.[8][9]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000116809 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000006215 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: ZBTB17 zinc finger and BTB domain containing 17".
  6. ^ Herold S, Wanzel M, Beuger V, Frohme C, Beul D, Hillukkala T, Syvaoja J, Saluz HP, Haenel F, Eilers M (Sep 2002). "Negative regulation of the mammalian UV response by Myc through association with Miz-1". Molecular Cell. 10 (3): 509–21. doi:10.1016/S1097-2765(02)00633-0. PMID 12408820.
  7. ^ Piluso D, Bilan P, Capone JP (Nov 2002). "Host cell factor-1 interacts with and antagonizes transactivation by the cell cycle regulatory factor Miz-1". The Journal of Biological Chemistry. 277 (48): 46799–808. doi:10.1074/jbc.M206226200. PMID 12244100.
  8. ^ Staller P, Peukert K, Kiermaier A, Seoane J, Lukas J, Karsunky H, Möröy T, Bartek J, Massagué J, Hänel F, Eilers M (Apr 2001). "Repression of p15INK4b expression by Myc through association with Miz-1". Nature Cell Biology. 3 (4): 392–9. doi:10.1038/35070076. PMID 11283613. S2CID 12696178.
  9. ^ Peukert K, Staller P, Schneider A, Carmichael G, Hänel F, Eilers M (Sep 1997). "An alternative pathway for gene regulation by Myc". The EMBO Journal. 16 (18): 5672–86. doi:10.1093/emboj/16.18.5672. PMC 1170199. PMID 9312026.

Further reading

  • Lichter P, Bray P, Ried T, Dawid IB, Ward DC (Aug 1992). "Clustering of C2-H2 zinc finger motif sequences within telomeric and fragile site regions of human chromosomes". Genomics. 13 (4): 999–1007. doi:10.1016/0888-7543(92)90013-I. PMID 1505991.
  • Bray P, Lichter P, Thiesen HJ, Ward DC, Dawid IB (Nov 1991). "Characterization and mapping of human genes encoding zinc finger proteins". Proceedings of the National Academy of Sciences of the United States of America. 88 (21): 9563–7. Bibcode:1991PNAS...88.9563B. doi:10.1073/pnas.88.21.9563. PMC 52758. PMID 1946370.
  • Tommerup N, Vissing H (May 1995). "Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs identify putative candidate genes for developmental and malignant disorders". Genomics. 27 (2): 259–64. doi:10.1006/geno.1995.1040. PMID 7557990.
  • Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Wu L, Wu H, Ma L, Sangiorgi F, Wu N, Bell JR, Lyons GE, Maxson R (Jul 1997). "Miz1, a novel zinc finger transcription factor that interacts with Msx2 and enhances its affinity for DNA". Mechanisms of Development. 65 (1–2): 3–17. doi:10.1016/S0925-4773(97)00032-4. PMID 9256341. S2CID 11835268.
  • Schneider A, Peukert K, Eilers M, Hänel F (1997). "Association of Myc with the Zinc-finger Protein Miz-1 Defines a Novel Pathway for Gene Regulation by Myc". C-Myc in B-Cell Neoplasia. Current Topics in Microbiology and Immunology. Vol. 224. pp. 137–46. doi:10.1007/978-3-642-60801-8_14. ISBN 978-3-642-64560-0. PMID 9308237.
  • Peukert K, Staller P, Schneider A, Carmichael G, Hänel F, Eilers M (Sep 1997). "An alternative pathway for gene regulation by Myc". The EMBO Journal. 16 (18): 5672–86. doi:10.1093/emboj/16.18.5672. PMC 1170199. PMID 9312026.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Sui D, Wilson JE (Oct 2000). "Interaction of insulin-like growth factor binding protein-4, Miz-1, leptin, lipocalin-type prostaglandin D synthase, and granulin precursor with the N-terminal half of type III hexokinase". Archives of Biochemistry and Biophysics. 382 (2): 262–74. doi:10.1006/abbi.2000.2019. PMID 11068878.
  • Staller P, Peukert K, Kiermaier A, Seoane J, Lukas J, Karsunky H, Möröy T, Bartek J, Massagué J, Hänel F, Eilers M (Apr 2001). "Repression of p15INK4b expression by Myc through association with Miz-1". Nature Cell Biology. 3 (4): 392–9. doi:10.1038/35070076. PMID 11283613. S2CID 12696178.
  • Ziegelbauer J, Shan B, Yager D, Larabell C, Hoffmann B, Tjian R (Aug 2001). "Transcription factor MIZ-1 is regulated via microtubule association". Molecular Cell. 8 (2): 339–49. doi:10.1016/S1097-2765(01)00313-6. PMID 11545736.
  • Tussie-Luna MI, Michel B, Hakre S, Roy AL (Nov 2002). "The SUMO ubiquitin-protein isopeptide ligase family member Miz1/PIASxbeta /Siz2 is a transcriptional cofactor for TFII-I". The Journal of Biological Chemistry. 277 (45): 43185–93. doi:10.1074/jbc.M207635200. PMID 12193603.
  • Piluso D, Bilan P, Capone JP (Nov 2002). "Host cell factor-1 interacts with and antagonizes transactivation by the cell cycle regulatory factor Miz-1". The Journal of Biological Chemistry. 277 (48): 46799–808. doi:10.1074/jbc.M206226200. PMID 12244100.
  • Zhang H, Li Z, Viklund EK, Strömblad S (Sep 2002). "P21-activated kinase 4 interacts with integrin alpha v beta 5 and regulates alpha v beta 5-mediated cell migration". The Journal of Cell Biology. 158 (7): 1287–97. doi:10.1083/jcb.200207008. PMC 2173231. PMID 12356872.
  • Herold S, Wanzel M, Beuger V, Frohme C, Beul D, Hillukkala T, Syvaoja J, Saluz HP, Haenel F, Eilers M (Sep 2002). "Negative regulation of the mammalian UV response by Myc through association with Miz-1". Molecular Cell. 10 (3): 509–21. doi:10.1016/S1097-2765(02)00633-0. PMID 12408820.
  • Wu S, Cetinkaya C, Munoz-Alonso MJ, von der Lehr N, Bahram F, Beuger V, Eilers M, Leon J, Larsson LG (Jan 2003). "Myc represses differentiation-induced p21CIP1 expression via Miz-1-dependent interaction with the p21 core promoter". Oncogene. 22 (3): 351–60. doi:10.1038/sj.onc.1206145. PMID 12545156. S2CID 903258.
  • Bowen H, Lapham A, Phillips E, Yeung I, Alter-Koltunoff M, Levi BZ, Perry VH, Mann DA, Barton CH (Sep 2003). "Characterization of the murine Nramp1 promoter: requirements for transactivation by Miz-1". The Journal of Biological Chemistry. 278 (38): 36017–26. doi:10.1074/jbc.M304301200. PMID 12840021.
  • Sakurai T, Itoh K, Higashitsuji H, Nagao T, Nonoguchi K, Chiba T, Fujita J (Apr 2004). "A cleaved form of MAGE-A4 binds to Miz-1 and induces apoptosis in human cells". The Journal of Biological Chemistry. 279 (15): 15505–14. doi:10.1074/jbc.M310437200. hdl:2433/147540. PMID 14739298.
  • Lehner B, Sanderson CM (Jul 2004). "A protein interaction framework for human mRNA degradation". Genome Research. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.

External links

  • ZBTB17+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
  • Overview of all the structural information available in the PDB for UniProt: Q13105 (Zinc finger and BTB domain-containing protein 17) at the PDBe-KB.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

  • v
  • t
  • e
(1) Basic domains
(1.1) Basic leucine zipper (bZIP)
(1.2) Basic helix-loop-helix (bHLH)
Group A
Group B
Group C
bHLH-PAS
Group D
Group E
Group F
bHLH-COE
(1.3) bHLH-ZIP
(1.4) NF-1
(1.5) RF-X
(1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger DNA-binding domains
(2.1) Nuclear receptor (Cys4)
subfamily 1
subfamily 2
subfamily 3
subfamily 4
subfamily 5
subfamily 6
subfamily 0
(2.2) Other Cys4
(2.3) Cys2His2
(2.4) Cys6
(2.5) Alternating composition
(2.6) WRKY
(3) Helix-turn-helix domains
(3.1) Homeodomain
Antennapedia
ANTP class
protoHOX
Hox-like
metaHOX
NK-like
other
(3.2) Paired box
(3.3) Fork head / winged helix
(3.4) Heat shock factors
(3.5) Tryptophan clusters
(3.6) TEA domain
  • transcriptional enhancer factor
(4) β-Scaffold factors with minor groove contacts
(4.1) Rel homology region
(4.2) STAT
(4.3) p53-like
(4.4) MADS box
(4.6) TATA-binding proteins
(4.7) High-mobility group
(4.9) Grainyhead
(4.10) Cold-shock domain
(4.11) Runt
(0) Other transcription factors
(0.2) HMGI(Y)
(0.3) Pocket domain
(0.5) AP-2/EREBP-related factors
(0.6) Miscellaneous
see also transcription factor/coregulator deficiencies


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