Octamer transcription factor

Group of proteins

Octamer transcription factors are a family of transcription factors which binds to the "ATTTGCAT" DNA sequence.[1] Their DNA-binding domain is a POU domain.

There are eight Octamer proteins in humans (Oct1–11),[2] which have been renamed according to the different classes of POU domain.[3] Octamer-3/4, also known as POU5F1, is one of the Yamanaka factors, which are critical for the maintenance and self-renewal of embryonic stem cells.[3] On the other hand, Oct-1 and Oct-2 are widely expressed in adult tissues.[3] Oct-7, 8 and 9, also known as "brain factors", are predominantly expressed in the central nervous system during embryonic development.[3] Oct-6 expression is confined to embryonic stem cells and the developing nervous system and skin, while Oct-11 is also involved in skin differentiation.[3]

Human Oct proteins

  • Oct-1 - POU2F1
  • Oct-2 - POU2F2
  • Oct-3/4 – POU5F1
  • Oct-6 – POU3F1
  • Oct-7 – POU3F2
  • Oct-8 – POU3F3
  • Oct-9 – POU3F4
  • Oct-11 – POU2F3

References

  1. ^ Petryniak B, Staudt LM, Postema CE, McCormack WT, Thompson CB (1990). "Characterization of chicken octamer-binding proteins demonstrates that POU domain-containing homeobox transcription factors have been highly conserved during vertebrate evolution". Proc. Natl. Acad. Sci. U.S.A. 87 (3): 1099–103. Bibcode:1990PNAS...87.1099P. doi:10.1073/pnas.87.3.1099. PMC 53418. PMID 1967834.
  2. ^ Oct-5 and Oct-10 are not found in humans, while Oct-3 and Oct-4 were identified as the same protein.
  3. ^ a b c d e Zhao, FQ (1 June 2013). "Octamer-binding transcription factors: genomics and functions". Frontiers in Bioscience (Landmark Edition). 18 (3): 1051–71. doi:10.2741/4162. PMC 4349413. PMID 23747866.

External links

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(1) Basic domains
(1.1) Basic leucine zipper (bZIP)
(1.2) Basic helix-loop-helix (bHLH)
Group A
Group B
Group C
bHLH-PAS
Group D
Group E
Group F
bHLH-COE
(1.3) bHLH-ZIP
(1.4) NF-1
(1.5) RF-X
(1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger DNA-binding domains
(2.1) Nuclear receptor (Cys4)
subfamily 1
subfamily 2
subfamily 3
subfamily 4
subfamily 5
subfamily 6
subfamily 0
(2.2) Other Cys4
(2.3) Cys2His2
(2.4) Cys6
(2.5) Alternating composition
(2.6) WRKY
(3) Helix-turn-helix domains
(3.1) Homeodomain
Antennapedia
ANTP class
protoHOX
Hox-like
metaHOX
NK-like
other
(3.2) Paired box
(3.3) Fork head / winged helix
(3.4) Heat shock factors
(3.5) Tryptophan clusters
(3.6) TEA domain
  • transcriptional enhancer factor
(4) β-Scaffold factors with minor groove contacts
(4.1) Rel homology region
(4.2) STAT
(4.3) p53-like
(4.4) MADS box
(4.6) TATA-binding proteins
(4.7) High-mobility group
(4.9) Grainyhead
(4.10) Cold-shock domain
(4.11) Runt
(0) Other transcription factors
(0.2) HMGI(Y)
(0.3) Pocket domain
(0.5) AP-2/EREBP-related factors
(0.6) Miscellaneous
see also transcription factor/coregulator deficiencies