HBP1

Protein-coding gene in the species Homo sapiens
HBP1
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2E6O, 3QVE

Identifiers
AliasesHBP1, HMG-box transcription factor 1
External IDsOMIM: 616714; MGI: 894659; HomoloGene: 8171; GeneCards: HBP1; OMA:HBP1 - orthologs
Gene location (Human)
Chromosome 7 (human)
Chr.Chromosome 7 (human)[1]
Chromosome 7 (human)
Genomic location for HBP1
Genomic location for HBP1
Band7q22.3Start107,168,961 bp[1]
End107,202,522 bp[1]
Gene location (Mouse)
Chromosome 12 (mouse)
Chr.Chromosome 12 (mouse)[2]
Chromosome 12 (mouse)
Genomic location for HBP1
Genomic location for HBP1
Band12|12 A3Start31,976,253 bp[2]
End32,000,534 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • Achilles tendon

  • right lung

  • skin of leg

  • skin of abdomen

  • bone marrow cells

  • tibial arteries

  • left testis

  • left ovary

  • gastric mucosa

  • right testis
Top expressed in
  • interventricular septum

  • vestibular sensory epithelium

  • epithelium of lens

  • carotid body

  • Rostral migratory stream

  • granulocyte

  • gastrula

  • lacrimal gland

  • Gonadal ridge

  • muscle of thigh
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • DNA binding
  • protein binding
  • RNA binding
  • DNA-binding transcription factor activity, RNA polymerase II-specific
Cellular component
  • nucleus
  • nucleoplasm
  • nuclear speck
Biological process
  • regulation of transcription, DNA-templated
  • Wnt signaling pathway
  • transcription, DNA-templated
  • regulation of transcription by RNA polymerase II
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

26959

73389

Ensembl

ENSG00000105856
ENSG00000283847

ENSMUSG00000002996

UniProt

O60381

Q8R316

RefSeq (mRNA)

NM_001244262
NM_012257

NM_153198
NM_177993
NM_001361928

RefSeq (protein)

NP_001231191
NP_036389

NP_694878
NP_818774
NP_001348857

Location (UCSC)Chr 7: 107.17 – 107.2 MbChr 12: 31.98 – 32 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

HMG-box transcription factor 1, also known as HBP1, is a human protein.[5]

Interactions

HBP1 has been shown to interact with SIN3A[6] and Retinoblastoma protein.[7]

References

  1. ^ a b c ENSG00000283847 GRCh38: Ensembl release 89: ENSG00000105856, ENSG00000283847 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000002996 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: HBP1 HMG-box transcription factor 1".
  6. ^ Swanson KA, Knoepfler Paul S, Huang Kai, Kang Richard S, Cowley Shaun M, Laherty Carol D, Eisenman Robert N, Radhakrishnan Ishwar (Aug 2004). "HBP1 and Mad1 repressors bind the Sin3 corepressor PAH2 domain with opposite helical orientations". Nat. Struct. Mol. Biol. 11 (8): 738–46. doi:10.1038/nsmb798. ISSN 1545-9993. PMID 15235594. S2CID 44324333.
  7. ^ Lavender P, Vandel L, Bannister A J, Kouzarides T (Jun 1997). "The HMG-box transcription factor HBP1 is targeted by the pocket proteins and E1A". Oncogene. 14 (22): 2721–8. doi:10.1038/sj.onc.1201243. ISSN 0950-9232. PMID 9178770.

Further reading

  • Tevosian SG, Shih HH, Mendelson KG, et al. (1997). "HBP1: a HMG box transcriptional repressor that is targeted by the retinoblastoma family". Genes Dev. 11 (3): 383–96. doi:10.1101/gad.11.3.383. PMID 9030690.
  • Lavender P, Vandel L, Bannister AJ, Kouzarides T (1997). "The HMG-box transcription factor HBP1 is targeted by the pocket proteins and E1A". Oncogene. 14 (22): 2721–8. doi:10.1038/sj.onc.1201243. PMID 9178770.
  • Zhuma T, Tyrrell R, Sekkali B, et al. (2000). "Human HMG box transcription factor HBP1: a role in hCD2 LCR function". EMBO J. 18 (22): 6396–406. doi:10.1093/emboj/18.22.6396. PMC 1171702. PMID 10562551.
  • Lemercier C, Duncliffe K, Boibessot I, et al. (2000). "Involvement of Retinoblastoma Protein and HBP1 in Histone H10 Gene Expression". Mol. Cell. Biol. 20 (18): 6627–37. doi:10.1128/MCB.20.18.6627-6637.2000. PMC 86159. PMID 10958660.
  • Shih HH, Xiu M, Berasi SP, et al. (2001). "HMG Box Transcriptional Repressor HBP1 Maintains a Proliferation Barrier in Differentiated Liver Tissue". Mol. Cell. Biol. 21 (17): 5723–32. doi:10.1128/MCB.21.17.5723-5732.2001. PMC 87292. PMID 11486012.
  • Sampson EM, Haque ZK, Ku MC, et al. (2001). "Negative regulation of the Wnt–β-catenin pathway by the transcriptional repressor HBP1". EMBO J. 20 (16): 4500–11. doi:10.1093/emboj/20.16.4500. PMC 125566. PMID 11500377.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. Bibcode:2003Natur.424..157H. doi:10.1038/nature01782. PMID 12853948.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • de Chiara C, Kelly G, Frenkiel TA, Pastore A (2004). "Assignment of the 1H, 13C, and 15N resonances of the AXH domain of the transcription factor HBP1". J. Biomol. NMR. 28 (4): 411–2. doi:10.1023/B:JNMR.0000015367.92295.0f. PMID 14872137. S2CID 43367627.
  • Berasi SP, Xiu M, Yee AS, Paulson KE (2004). "HBP1 Repression of the p47phox Gene: Cell Cycle Regulation via the NADPH Oxidase". Mol. Cell. Biol. 24 (7): 3011–24. doi:10.1128/MCB.24.7.3011-3024.2004. PMC 371097. PMID 15024088.
  • Colland F, Jacq X, Trouplin V, et al. (2004). "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
  • Swanson KA, Knoepfler PS, Huang K, et al. (2004). "HBP1 and Mad1 repressors bind the Sin3 corepressor PAH2 domain with opposite helical orientations". Nat. Struct. Mol. Biol. 11 (8): 738–46. doi:10.1038/nsmb798. PMID 15235594. S2CID 44324333.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Yao CJ, Works K, Romagnoli PA, Austin GE (2005). "Effects of overexpression of HBP1 upon growth and differentiation of leukemic myeloid cells". Leukemia. 19 (11): 1958–68. doi:10.1038/sj.leu.2403918. PMID 16179914. S2CID 10030062.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein–protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Sekkali B, Szabat E, Ktistaki E, et al. (2005). "Human high mobility group box transcription factor 1 affects thymocyte development and transgene variegation". J. Immunol. 175 (8): 5203–12. doi:10.4049/jimmunol.175.8.5203. PMID 16210625.
  • Kim J, Zhang X, Rieger-Christ KM, et al. (2006). "Suppression of Wnt signaling by the green tea compound (-)-epigallocatechin 3-gallate (EGCG) in invasive breast cancer cells. Requirement of the transcriptional repressor HBP1". J. Biol. Chem. 281 (16): 10865–75. doi:10.1074/jbc.M513378200. PMID 16495219.
  • Lim J, Hao T, Shaw C, et al. (2006). "A protein–protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.
  • Zhang X, Kim J, Ruthazer R, et al. (2007). "The HBP1 Transcriptional Repressor Participates in RAS-Induced Premature Senescence". Mol. Cell. Biol. 26 (22): 8252–66. doi:10.1128/MCB.00604-06. PMC 1636767. PMID 16966377.
  • v
  • t
  • e
  • 1v06: AXH DOMAIN OF THE TRANSCRIPTION FACTOR HBP1 FROM M.MUSCULUS
    1v06: AXH DOMAIN OF THE TRANSCRIPTION FACTOR HBP1 FROM M.MUSCULUS

External links

  • v
  • t
  • e
(1) Basic domains
(1.1) Basic leucine zipper (bZIP)
(1.2) Basic helix-loop-helix (bHLH)
Group A
Group B
Group C
bHLH-PAS
Group D
Group E
Group F
bHLH-COE
(1.3) bHLH-ZIP
(1.4) NF-1
(1.5) RF-X
(1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger DNA-binding domains
(2.1) Nuclear receptor (Cys4)
subfamily 1
subfamily 2
subfamily 3
subfamily 4
subfamily 5
subfamily 6
subfamily 0
(2.2) Other Cys4
(2.3) Cys2His2
(2.4) Cys6
(2.5) Alternating composition
(2.6) WRKY
(3) Helix-turn-helix domains
(3.1) Homeodomain
Antennapedia
ANTP class
protoHOX
Hox-like
metaHOX
NK-like
other
(3.2) Paired box
(3.3) Fork head / winged helix
(3.4) Heat shock factors
(3.5) Tryptophan clusters
(3.6) TEA domain
  • transcriptional enhancer factor
(4) β-Scaffold factors with minor groove contacts
(4.1) Rel homology region
(4.2) STAT
(4.3) p53-like
(4.4) MADS box
(4.6) TATA-binding proteins
(4.7) High-mobility group
(4.9) Grainyhead
(4.10) Cold-shock domain
(4.11) Runt
(0) Other transcription factors
(0.2) HMGI(Y)
(0.3) Pocket domain
(0.5) AP-2/EREBP-related factors
(0.6) Miscellaneous
see also transcription factor/coregulator deficiencies


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