KAT6B

Protein-coding gene in the species Homo sapiens
KAT6B
Identifiers
AliasesKAT6B, GTPTS, MORF, MOZ2, MYST4, ZC2HC6B, qkf, querkopf, lysine acetyltransferase 6B
External IDsOMIM: 605880; MGI: 1858746; HomoloGene: 49310; GeneCards: KAT6B; OMA:KAT6B - orthologs
Gene location (Human)
Chromosome 10 (human)
Chr.Chromosome 10 (human)[1]
Chromosome 10 (human)
Genomic location for KAT6B
Genomic location for KAT6B
Band10q22.2Start74,824,927 bp[1]
End75,032,624 bp[1]
Gene location (Mouse)
Chromosome 14 (mouse)
Chr.Chromosome 14 (mouse)[2]
Chromosome 14 (mouse)
Genomic location for KAT6B
Genomic location for KAT6B
Band14|14 A3Start21,531,502 bp[2]
End21,722,546 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • ventricular zone

  • sural nerve

  • bone marrow cells

  • corpus callosum

  • ganglionic eminence

  • testicle

  • epithelium of colon

  • skeletal muscle tissue

  • stromal cell of endometrium

  • tonsil
Top expressed in
  • zygote

  • ventricular zone

  • genital tubercle

  • tail of embryo

  • blastocyst

  • neural layer of retina

  • morula

  • superior frontal gyrus

  • dentate gyrus of hippocampal formation granule cell

  • spermatocyte
More reference expression data
BioGPS




More reference expression data
Gene ontology
Molecular function
  • transferase activity
  • DNA binding
  • transcription factor binding
  • metal ion binding
  • histone acetyltransferase activity
  • protein binding
  • acetyltransferase activity
  • acyltransferase activity
  • protein-containing complex binding
  • H4 histone acetyltransferase activity
  • histone binding
Cellular component
  • nucleoplasm
  • nucleosome
  • MOZ/MORF histone acetyltransferase complex
  • nucleus
  • histone acetyltransferase complex
Biological process
  • nucleosome assembly
  • regulation of transcription, DNA-templated
  • transcription, DNA-templated
  • positive regulation of transcription, DNA-templated
  • histone acetylation
  • histone H3 acetylation
  • negative regulation of transcription, DNA-templated
  • positive regulation of transcription by RNA polymerase II
  • cellular response to leukemia inhibitory factor
  • chromatin organization
  • histone H4 acetylation
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

23522

54169

Ensembl

ENSG00000156650
ENSG00000281813

ENSMUSG00000021767

UniProt

Q8WYB5

Q8BRB7

RefSeq (mRNA)

NM_001256468
NM_001256469
NM_012330

NM_001205241
NM_017479

RefSeq (protein)

NP_001243397
NP_001243398
NP_036462

NP_001192170
NP_059507

Location (UCSC)Chr 10: 74.82 – 75.03 MbChr 14: 21.53 – 21.72 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

K(lysine) acetyltransferase 6B (KAT6B) is an enzyme that in humans is encoded by the KAT6B gene.[5][6][7]

Interactions

KAT6B has been shown to interact with RUNX2.[8]

Clinical significance

It has been demonstrated that de novo mutations in the gene KAT6B causes Young–Simpson syndrome and genitopatellar syndrome.[9][10][11][12][13]

References

  1. ^ a b c ENSG00000281813 GRCh38: Ensembl release 89: ENSG00000156650, ENSG00000281813 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021767 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Nagase T, Ishikawa K, Nakajima D, Ohira M, Seki N, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Sep 1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 4 (2): 141–50. doi:10.1093/dnares/4.2.141. PMID 9205841.
  6. ^ Champagne N, Bertos NR, Pelletier N, Wang AH, Vezmar M, Yang Y, Heng HH, Yang XJ (Nov 1999). "Identification of a human histone acetyltransferase related to monocytic leukemia zinc finger protein". J Biol Chem. 274 (40): 28528–36. doi:10.1074/jbc.274.40.28528. PMID 10497217.
  7. ^ "Entrez Gene: MYST4 MYST histone acetyltransferase (monocytic leukemia) 4".
  8. ^ Pelletier N, Champagne N, Stifani S, Yang XJ (Apr 2002). "MOZ and MORF histone acetyltransferases interact with the Runt-domain transcription factor Runx2". Oncogene. 21 (17): 2729–40. doi:10.1038/sj.onc.1205367. PMID 11965546. S2CID 19597517.
  9. ^ Campeau PM, Kim JC, Lu JT, Schwartzentruber JA, Abdul-Rahman OA, Schlaubitz S, Murdock DM, Jiang MM, Lammer EJ, Enns GM, Rhead WJ, Rowland J, Robertson SP, Cormier-Daire V, Bainbridge MN, Yang XJ, Gingras MC, Gibbs RA, Rosenblatt DS, Majewski J, Lee BH (Jan 18, 2012). "Mutations in KAT6B, Encoding a Histone Acetyltransferase, Cause Genitopatellar Syndrome". American Journal of Human Genetics. 90 (2): 282–9. doi:10.1016/j.ajhg.2011.11.023. PMC 3276659. PMID 22265014.
  10. ^ Clayton-Smith J, O'Sullivan J, Daly S, Bhaskar S, Day R, Anderson B, Voss AK, Thomas T, Biesecker LG, Smith P, Fryer A, Chandler KE, Kerr B, Tassabehji M, Lynch SA, Krajewska-Walasek M, McKee S, Smith J, Sweeney E, Mansour S, Mohammed S, Donnai D, Black G (Nov 2011). "Whole-Exome-Sequencing Identifies Mutations in Histone Acetyltransferase Gene KAT6B in Individuals with the Say-Barber-Biesecker Variant of Ohdo Syndrome". Am. J. Hum. Genet. 89 (5): 675–81. doi:10.1016/j.ajhg.2011.10.008. PMC 3213399. PMID 22077973.
  11. ^ Campeau PM, Kim JC, Lu JT, Schwartzentruber JA, Abdul-Rahman OA, Schlaubitz S, Murdock DM, Jiang MM, Lammer EJ, Enns GM, Rhead WJ, Rowland J, Robertson SP, Cormier-Daire V, Bainbridge MN, Yang XJ, Gingras MC, Gibbs RA, Rosenblatt DS, Majewski J, Lee BH (Jan 2012). "Mutations in KAT6B, Encoding a Histone Acetyltransferase, Cause Genitopatellar Syndrome". American Journal of Human Genetics. 90 (2): 282–9. doi:10.1016/j.ajhg.2011.11.023. PMC 3276659. PMID 22265014.
  12. ^ Campeau PM, Lu JT, Dawson BC, Fokkema IF, Robertson SP, Gibbs RA, Lee BH (Jun 19, 2012). "The KAT6B-related disorders Genitopatellar syndrome and Ohdo/SBBYS syndrome have distinct clinical features reflecting distinct molecular mechanisms". Human Mutation. 33 (11): 1520–5. doi:10.1002/humu.22141. PMC 3696352. PMID 22715153.
  13. ^ Mendez R, Delea M, Dain L, Rittler M (January 2020). "A novel pathogenic frameshift variant of KAT6B identified by clinical exome sequencing in a newborn with the Say–Barber–Biesecker–Young–Simpson syndrome". Clinical Dysmorphology. 29 (1): 42–45. doi:10.1097/mcd.0000000000000270. PMID 30921092. S2CID 85565150.

Further reading

  • Pena AN, Pereira-Smith OM (2007). "The role of the MORF/MRG family of genes in cell growth, differentiation, DNA repair, and thereby aging". Ann. N. Y. Acad. Sci. 1100 (1): 299–305. Bibcode:2007NYASA1100..299P. doi:10.1196/annals.1395.031. PMID 17460191. S2CID 12635963.
  • Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
  • Topper M, Luo Y, Zhadina M, Mohammed K, Smith L, Muesing MA (2007). "Posttranslational Acetylation of the Human Immunodeficiency Virus Type 1 Integrase Carboxyl-Terminal Domain Is Dispensable for Viral Replication". J. Virol. 81 (6): 3012–7. doi:10.1128/JVI.02257-06. PMC 1865993. PMID 17182677.
  • Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
  • Cereseto A, Manganaro L, Gutierrez MI, Terreni M, Fittipaldi A, Lusic M, Marcello A, Giacca M (2005). "Acetylation of HIV-1 integrase by p300 regulates viral integration". EMBO J. 24 (17): 3070–81. doi:10.1038/sj.emboj.7600770. PMC 1201351. PMID 16096645.
  • Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
  • Liu C, Lu J, Tan J, Li L, Huang B (2005). "Human interleukin-5 expression is synergistically regulated by histone acetyltransferase CBP/p300 and transcription factors C/EBP, NF-AT and AP-1". Cytokine. 27 (4–5): 93–100. doi:10.1016/j.cyto.2004.02.003. PMID 15271374.
  • Pelletier N, Champagne N, Stifani S, Yang XJ (2002). "MOZ and MORF histone acetyltransferases interact with the Runt-domain transcription factor Runx2". Oncogene. 21 (17): 2729–40. doi:10.1038/sj.onc.1205367. PMID 11965546. S2CID 19597517.
  • Panagopoulos I, Fioretos T, Isaksson M, Samuelsson U, Billström R, Strömbeck B, Mitelman F, Johansson B (2001). "Fusion of the MORF and CBP genes in acute myeloid leukemia with the t(10;16)(q22;p13)". Hum. Mol. Genet. 10 (4): 395–404. doi:10.1093/hmg/10.4.395. PMID 11157802.

External links

  • MYST4+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
  • Overview of all the structural information available in the PDB for UniProt: Q8WYB5 (Histone acetyltransferase KAT6B) at the PDBe-KB.


This article incorporates text from the United States National Library of Medicine, which is in the public domain.

  • v
  • t
  • e
(1) Basic domains
(1.1) Basic leucine zipper (bZIP)
(1.2) Basic helix-loop-helix (bHLH)
Group A
Group B
Group C
bHLH-PAS
Group D
Group E
Group F
bHLH-COE
(1.3) bHLH-ZIP
(1.4) NF-1
(1.5) RF-X
(1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger DNA-binding domains
(2.1) Nuclear receptor (Cys4)
subfamily 1
subfamily 2
subfamily 3
subfamily 4
subfamily 5
subfamily 6
subfamily 0
(2.2) Other Cys4
(2.3) Cys2His2
(2.4) Cys6
(2.5) Alternating composition
(2.6) WRKY
(3) Helix-turn-helix domains
(3.1) Homeodomain
Antennapedia
ANTP class
protoHOX
Hox-like
metaHOX
NK-like
other
(3.2) Paired box
(3.3) Fork head / winged helix
(3.4) Heat shock factors
(3.5) Tryptophan clusters
(3.6) TEA domain
  • transcriptional enhancer factor
(4) β-Scaffold factors with minor groove contacts
(4.1) Rel homology region
(4.2) STAT
(4.3) p53-like
(4.4) MADS box
(4.6) TATA-binding proteins
(4.7) High-mobility group
(4.9) Grainyhead
(4.10) Cold-shock domain
(4.11) Runt
(0) Other transcription factors
(0.2) HMGI(Y)
(0.3) Pocket domain
(0.5) AP-2/EREBP-related factors
(0.6) Miscellaneous
see also transcription factor/coregulator deficiencies


Stub icon

This article on a gene on human chromosome 10 is a stub. You can help Wikipedia by expanding it.

  • v
  • t
  • e