KIF4B

Motor protein found in humans
KIF4B
Identifiers
AliasesKIF4B, kinesin family member 4B
External IDsOMIM: 609184 HomoloGene: 129673 GeneCards: KIF4B
Gene location (Human)
Chromosome 5 (human)
Chr.Chromosome 5 (human)[1]
Chromosome 5 (human)
Genomic location for KIF4B
Genomic location for KIF4B
Band5q33.2Start155,013,755 bp[1]
End155,018,141 bp[1]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • testicle
    n/a
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • microtubule binding
  • DNA binding
  • nucleotide binding
  • ATP binding
  • plus-end-directed microtubule motor activity
  • microtubule motor activity
  • ATPase activity
Cellular component
  • nuclear matrix
  • cytoplasm
  • cytosol
  • microtubule
  • cytoskeleton
  • kinesin complex
  • nucleus
  • nucleoplasm
  • intercellular bridge
Biological process
  • mitotic cytokinesis
  • microtubule-based movement
  • antigen processing and presentation of exogenous peptide antigen via MHC class II
  • mitotic spindle midzone assembly
  • retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
  • mitotic spindle organization
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

285643

n/a

Ensembl

ENSG00000226650

n/a

UniProt

Q2VIQ3

n/a

RefSeq (mRNA)

NM_001099293

n/a

RefSeq (protein)

NP_001092763

n/a

Location (UCSC)Chr 5: 155.01 – 155.02 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

KIF4B is a human protein encoded by the gene KIF4B. It is part of the kinesin family of motor proteins.

Function

KIF4B and the closely related protein KIF4A are essential for regulating anaphase spindle dynamics during mitosis.[3]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000226650 – Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ Zhu, Changjun; Zhao, Jian; Bibikova, Marina; Leverson, Joel D.; Bossy-Wetzel, Ella; Fan, Jian-Bing; Abraham, Robert T.; Jiang, Wei (July 2005). "Functional Analysis of Human Microtubule-based Motor Proteins, the Kinesins and Dyneins, in Mitosis/Cytokinesis Using RNA Interference". Molecular Biology of the Cell. 16 (7): 3187–3199. doi:10.1091/mbc.e05-02-0167. ISSN 1059-1524. PMC 1165403. PMID 15843429.
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Human
Microfilaments
and ABPs
Myofilament
Actins
Myosins
Other
Other
Intermediate
filaments
Type 1/2
(Keratin,
Cytokeratin)
Epithelial keratins
(soft alpha-keratins)
Hair keratins
(hard alpha-keratins)
Ungrouped alpha
Not alpha
Type 3
Type 4
Type 5
Microtubules
and MAPs
Tubulins
MAPs
Kinesins
Dyneins
Microtubule organising proteins
Microtubule severing proteins
Other
Catenins
Membrane
Other
Nonhuman
See also: cytoskeletal defects


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