MYH15

Protein-coding gene in the species Homo sapiens
MYH15
Identifiers
AliasesMYH15, myosin heavy chain 15
External IDsOMIM: 609929; MGI: 3643515; HomoloGene: 18929; GeneCards: MYH15; OMA:MYH15 - orthologs
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for MYH15
Genomic location for MYH15
Band3q13.13Start108,380,368 bp[1]
End108,529,322 bp[1]
Gene location (Mouse)
Chromosome 16 (mouse)
Chr.Chromosome 16 (mouse)[2]
Chromosome 16 (mouse)
Genomic location for MYH15
Genomic location for MYH15
Band16|16 B5Start48,877,849 bp[2]
End49,019,467 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • frontal pole

  • middle frontal gyrus

  • optic nerve

  • rectum

  • prefrontal cortex

  • cingulate gyrus

  • amygdala

  • cerebellar vermis

  • putamen

  • corpus callosum
Top expressed in
  • spermatid

  • secondary oocyte

  • testicle

  • lens

  • hypothalamus

  • hippocampus proper

  • olfactory bulb

  • spermatocyte
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • nucleotide binding
  • actin binding
  • cytoskeletal motor activity
  • ATP binding
  • calmodulin binding
  • actin filament binding
  • microtubule motor activity
  • microtubule binding
Cellular component
  • cytoplasm
  • myosin filament
  • myofibril
  • myosin complex
Biological process
  • extraocular skeletal muscle development
  • microtubule-based movement
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

22989

667772

Ensembl

ENSG00000144821

ENSMUSG00000092009

UniProt

Q9Y2K3

E9Q264

RefSeq (mRNA)

NM_014981

NM_001166210

RefSeq (protein)

NP_055796

NP_001159682

Location (UCSC)Chr 3: 108.38 – 108.53 MbChr 16: 48.88 – 49.02 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Myosin-15 also known as myosin, heavy chain 15 is a protein that in humans is encoded by the MYH15 gene.[5]

Function

MYH15 is a slow-twitch myosin.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000144821 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000092009 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Desjardins PR, Burkman JM, Shrager JB, Allmond LA, Stedman HH (April 2002). "Evolutionary implications of three novel members of the human sarcomeric myosin heavy chain gene family". Mol. Biol. Evol. 19 (4): 375–93. doi:10.1093/oxfordjournals.molbev.a004093. PMID 11919279.

Further reading

  • Luke MM, O'Meara ES, Rowland CM, et al. (2009). "Gene variants associated with ischemic stroke: the cardiovascular health study". Stroke. 40 (2): 363–8. doi:10.1161/STROKEAHA.108.521328. PMC 2881155. PMID 19023099.
  • Rossi AC, Mammucari C, Argentini C, et al. (2010). "Two novel/ancient myosins in mammalian skeletal muscles: MYH14/7b and MYH15 are expressed in extraocular muscles and muscle spindles". J. Physiol. 588 (Pt 2): 353–64. doi:10.1113/jphysiol.2009.181008. PMC 2821527. PMID 19948655.
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
  • Stedman HH, Kozyak BW, Nelson A, et al. (2004). "Myosin gene mutation correlates with anatomical changes in the human lineage". Nature. 428 (6981): 415–8. Bibcode:2004Natur.428..415S. doi:10.1038/nature02358. PMID 15042088. S2CID 4304466.
  • Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (1): 63–70. doi:10.1093/dnares/6.1.63. PMID 10231032.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • McGuigan K, Phillips PC, Postlethwait JH (2004). "Evolution of sarcomeric myosin heavy chain genes: evidence from fish". Mol. Biol. Evol. 21 (6): 1042–56. doi:10.1093/molbev/msh103. PMID 15014174.
  • Shiffman D, O'Meara ES, Bare LA, et al. (2008). "Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study". Arterioscler. Thromb. Vasc. Biol. 28 (1): 173–9. doi:10.1161/ATVBAHA.107.153981. PMC 2636623. PMID 17975119.
  • Bare LA, Morrison AC, Rowland CM, et al. (2007). "Five common gene variants identify elevated genetic risk for coronary heart disease". Genet. Med. 9 (10): 682–9. doi:10.1097/GIM.0b013e318156fb62. PMID 18073581.
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Human
Microfilaments
and ABPs
Myofilament
Actins
Myosins
Other
Other
Intermediate
filaments
Type 1/2
(Keratin,
Cytokeratin)
Epithelial keratins
(soft alpha-keratins)
Hair keratins
(hard alpha-keratins)
Ungrouped alpha
Not alpha
Type 3
Type 4
Type 5
Microtubules
and MAPs
Tubulins
MAPs
Kinesins
Dyneins
Microtubule organising proteins
Microtubule severing proteins
Other
Catenins
Membrane
Other
Nonhuman
See also: cytoskeletal defects


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