MYL6B

Protein-coding gene in the species Homo sapiens
MYL6B
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

1OE9, 1W7I, 1W7J

Identifiers
AliasesMYL6B, MLC1SA, myosin light chain 6B
External IDsOMIM: 609930 MGI: 1917789 HomoloGene: 86887 GeneCards: MYL6B
Gene location (Human)
Chromosome 12 (human)
Chr.Chromosome 12 (human)[1]
Chromosome 12 (human)
Genomic location for MYL6B
Genomic location for MYL6B
Band12q13.2Start56,152,256 bp[1]
End56,159,647 bp[1]
Gene location (Mouse)
Chromosome 10 (mouse)
Chr.Chromosome 10 (mouse)[2]
Chromosome 10 (mouse)
Genomic location for MYL6B
Genomic location for MYL6B
Band10|10 D3Start128,330,026 bp[2]
End128,334,554 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • thoracic diaphragm

  • ganglionic eminence

  • tibialis anterior muscle

  • deltoid muscle

  • nucleus accumbens

  • vastus lateralis muscle

  • gastrocnemius muscle

  • body of tongue

  • caudate nucleus

  • putamen
Top expressed in
  • thoracic diaphragm

  • hypothalamus

  • white adipose tissue

  • testicle

  • ganglionic eminence

  • synovial joint

  • ankle joint

  • muscle tissue

  • lens

  • skeletal muscle tissue
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • calcium ion binding
  • structural constituent of muscle
  • cytoskeletal motor activity
  • protein binding
Cellular component
  • cytosol
  • muscle myosin complex
  • unconventional myosin complex
  • extracellular exosome
  • myosin complex
Biological process
  • muscle contraction
  • skeletal muscle tissue development
  • muscle filament sliding
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

140465

216459

Ensembl

ENSG00000196465

ENSMUSG00000039824

UniProt

P14649

Q8CI43

RefSeq (mRNA)

NM_002475
NM_001199629

NM_172259

RefSeq (protein)

NP_001186558
NP_002466

NP_758463

Location (UCSC)Chr 12: 56.15 – 56.16 MbChr 10: 128.33 – 128.33 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Myosin light chain 6B is a protein that in humans is encoded by the MYL6B gene.[5][6][7] Myosin is a hexameric ATPase cellular motor protein. It is composed of two heavy chains, two nonphosphorylatable alkali light chains, and two phosphorylatable regulatory light chains. This gene encodes a myosin alkali light chain expressed in both slow-twitch skeletal muscle and in nonmuscle tissue.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000196465 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000039824 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Zimmermann K, Starzinski-Powitz A (Feb 1990). "A novel isoform of myosin alkali light chain isolated from human muscle cells". Nucleic Acids Res. 17 (24): 10496. doi:10.1093/nar/17.24.10496. PMC 335321. PMID 2602161.
  6. ^ Hailstones DL, Gunning PW (Mar 1990). "Characterization of human myosin light chains 1sa and 3nm: implications for isoform evolution and function". Mol Cell Biol. 10 (3): 1095–104. doi:10.1128/mcb.10.3.1095. PMC 360973. PMID 2304459.
  7. ^ a b "Entrez Gene: MYL6B myosin, light chain 6B, alkali, smooth muscle and non-muscle".

Further reading

  • Coureux PD, Sweeney HL, Houdusse A (2005). "Three myosin V structures delineate essential features of chemo-mechanical transduction". EMBO J. 23 (23): 4527–37. doi:10.1038/sj.emboj.7600458. PMC 533045. PMID 15510214.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Komiyama M, Soldati T, von Arx P, Perriard JC (1997). "The intracompartmental sorting of myosin alkali light chain isoproteins reflects the sequence of developmental expression as determined by double epitope-tagging competition". J. Cell Sci. 109 (8): 2089–99. doi:10.1242/jcs.109.8.2089. PMID 8856505.
  • Seidel U, Bober E, Winter B, et al. (1988). "Alkali myosin light chains in man are encoded by a multigene family that includes the adult skeletal muscle, the embryonic or atrial, and nonsarcomeric isoforms". Gene. 66 (1): 135–46. doi:10.1016/0378-1119(88)90231-4. PMID 2458299.

External links

  • Overview of all the structural information available in the PDB for UniProt: P14649 (Human Myosin light chain 6B (MYL6B)) at the PDBe-KB.
  • v
  • t
  • e
  • 1oe9: CRYSTAL STRUCTURE OF MYOSIN V MOTOR WITH ESSENTIAL LIGHT CHAIN - NUCLEOTIDE-FREE
    1oe9: CRYSTAL STRUCTURE OF MYOSIN V MOTOR WITH ESSENTIAL LIGHT CHAIN - NUCLEOTIDE-FREE
  • 1w7i: CRYSTAL STRUCTURE OF MYOSIN V MOTOR WITHOUT NUCLEOTIDE SOAKED IN 10 MM MGADP
    1w7i: CRYSTAL STRUCTURE OF MYOSIN V MOTOR WITHOUT NUCLEOTIDE SOAKED IN 10 MM MGADP
  • 1w7j: CRYSTAL STRUCTURE OF MYOSIN V MOTOR WITH ESSENTIAL LIGHT CHAIN + ADP-BEFX - NEAR RIGOR
    1w7j: CRYSTAL STRUCTURE OF MYOSIN V MOTOR WITH ESSENTIAL LIGHT CHAIN + ADP-BEFX - NEAR RIGOR
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Human
Microfilaments
and ABPs
Myofilament
Actins
Myosins
Other
Other
Intermediate
filaments
Type 1/2
(Keratin,
Cytokeratin)
Epithelial keratins
(soft alpha-keratins)
Hair keratins
(hard alpha-keratins)
Ungrouped alpha
Not alpha
Type 3
Type 4
Type 5
Microtubules
and MAPs
Tubulins
MAPs
Kinesins
Dyneins
Microtubule organising proteins
Microtubule severing proteins
Other
Catenins
Membrane
Other
Nonhuman
See also: cytoskeletal defects
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