MYO1B

Protein-coding gene in the species Homo sapiens
MYO1B
Identifiers
AliasesMYO1B, myr1, myosin IB, MMIa, MMI-alpha, MYH-1c
External IDsOMIM: 606537; MGI: 107752; HomoloGene: 7856; GeneCards: MYO1B; OMA:MYO1B - orthologs
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for MYO1B
Genomic location for MYO1B
Band2q32.3Start191,245,185 bp[1]
End191,425,389 bp[1]
Gene location (Mouse)
Chromosome 1 (mouse)
Chr.Chromosome 1 (mouse)[2]
Chromosome 1 (mouse)
Genomic location for MYO1B
Genomic location for MYO1B
Band1 C1.1|1 26.58 cMStart51,788,924 bp[2]
End51,955,230 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • visceral pleura

  • liver

  • right lobe of liver

  • islet of Langerhans

  • lower lobe of lung

  • right lung

  • hair follicle

  • stromal cell of endometrium

  • tibia

  • parietal pleura
Top expressed in
  • right lung

  • lens

  • right lung lobe

  • seminal vesicula

  • left lung

  • left lobe of liver

  • calvaria

  • sciatic nerve

  • maxillary prominence

  • ganglionic eminence
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • nucleotide binding
  • calmodulin binding
  • microfilament motor activity
  • actin binding
  • phosphatidylinositol-4,5-bisphosphate binding
  • cytoskeletal motor activity
  • ATP binding
  • phosphatidylinositol-3,4,5-trisphosphate binding
  • actin filament binding
  • cadherin binding
Cellular component
  • cytoplasm
  • trans-Golgi network membrane
  • filopodium
  • early endosome
  • brush border
  • actin filament
  • perinuclear region of cytoplasm
  • endosome membrane
  • extracellular exosome
  • cell periphery
  • myosin complex
  • plasma membrane
  • apical part of cell
Biological process
  • actin filament organization
  • actin filament-based movement
  • actin filament bundle assembly
  • post-Golgi vesicle-mediated transport
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

4430

17912

Ensembl

ENSG00000128641

ENSMUSG00000018417

UniProt

O43795

P46735

RefSeq (mRNA)

NM_001130158
NM_001161819
NM_012223
NM_001330237
NM_001330238

NM_001161817
NM_001290982
NM_010863

RefSeq (protein)

NP_001123630
NP_001155291
NP_001317166
NP_001317167
NP_036355

NP_001155289
NP_001277911
NP_034993

Location (UCSC)Chr 2: 191.25 – 191.43 MbChr 1: 51.79 – 51.96 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Myosin-Ib is a protein that in humans is encoded by the MYO1B gene.[5][6][7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000128641 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000018417 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Bement WM, Hasson T, Wirth JA, et al. (Aug 1994). "Identification and overlapping expression of multiple unconventional myosin genes in vertebrate cell types". Proc Natl Acad Sci U S A. 91 (14): 6549–53. Bibcode:1994PNAS...91.6549B. doi:10.1073/pnas.91.14.6549. PMC 44240. PMID 8022818.
  6. ^ Ruppert C, Kroschewski R, Bahler M (Apr 1993). "Identification, characterization and cloning of myr 1, a mammalian myosin-I". J Cell Biol. 120 (6): 1393–403. doi:10.1083/jcb.120.6.1393. PMC 2119751. PMID 8449985.
  7. ^ "Entrez Gene: MYO1B myosin IB".

Further reading

  • Ruppert C, Godel J, Müller RT, et al. (1997). "Localization of the rat myosin I molecules myr 1 and myr 2 and in vivo targeting of their tail domains". J. Cell Sci. 108 (12): 3775–86. doi:10.1242/jcs.108.12.3775. PMID 8719884.
  • Tang N, Ostap EM (2001). "Motor domain-dependent localization of myo1b (myr-1)". Curr. Biol. 11 (14): 1131–5. Bibcode:2001CBio...11.1131T. doi:10.1016/S0960-9822(01)00320-7. PMID 11509238. S2CID 2678512.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Dumont RA, Zhao YD, Holt JR, et al. (2003). "Myosin-I isozymes in neonatal rodent auditory and vestibular epithelia". J. Assoc. Res. Otolaryngol. 3 (4): 375–89. doi:10.1007/s101620020049. PMC 3202438. PMID 12486594.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Salas-Cortes L, Ye F, Tenza D, et al. (2006). "Myosin Ib modulates the morphology and the protein transport within multi-vesicular sorting endosomes". J. Cell Sci. 118 (Pt 20): 4823–32. doi:10.1242/jcs.02607. PMID 16219689. S2CID 14698224.
  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
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Human
Microfilaments
and ABPs
Myofilament
Actins
Myosins
Other
Other
Intermediate
filaments
Type 1/2
(Keratin,
Cytokeratin)
Epithelial keratins
(soft alpha-keratins)
Hair keratins
(hard alpha-keratins)
Ungrouped alpha
Not alpha
Type 3
Type 4
Type 5
Microtubules
and MAPs
Tubulins
MAPs
Kinesins
Dyneins
Microtubule organising proteins
Microtubule severing proteins
Other
Catenins
Membrane
Other
Nonhuman
See also: cytoskeletal defects


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